Limited proteolysis of MP26 in Lens fiber plasma membranes of the u18666a-induced cataract in rats

Document Type

Article

Publication Title

Current Eye Research

Abstract

Most of the animals treated with U18666A every other day beginning at one-day of age developed permanent nuclear cataracts by 3-4 weeks of age. Lens fiber plasma membranes were isolated from cortical and nuclear areas of untreated controls, treated but clear, and treated cataractous lenses, and analyzed by SDS-PAGE. MP26 was the major intrinsic polypeptide in the plasma membranes of both cortical and nuclear fibers of control lenses. MP26 was largely replaced by MP23-24 in the plasma membranes of nuclear fibers of treated but clear lenses, and in the membranes of both cortical and nuclear fibers of cataractous lenses. © 1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

First Page

1001

Last Page

1006

DOI

10.3109/02713689509000008

Publication Date

1-1-1985

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