Long-lasting blockade of P2-receptors of the urinary bladder in vivo following photolysis of arylazido aminopropionyl atp, a photoaffinity label
Document Type
Article
Publication Title
Life Sciences
Abstract
In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the bladders with visible light during the infusion of ANAPP3 resulted in a blockade of the response for at least 120 minutes. Thus, photoactivation of ANAPP3 in vivo produced an essentially irreversible blockade of P2-purinergic receptors. © 1986.
First Page
1591
Last Page
1595
DOI
10.1016/0024-3205(86)90498-4
Publication Date
4-28-1986
Recommended Citation
Theobald, Robert J. and Hoffman, Victor, "Long-lasting blockade of P2-receptors of the urinary bladder in vivo following photolysis of arylazido aminopropionyl atp, a photoaffinity label" (1986). All KCOM Faculty Publications. 408.
https://scholarworks.atsu.edu/kcom-faculty/408