Pharmacological studies to examine the source of ATP released by pelvic nerve stimulation in the feline lower urinary tract

Document Type

Article

Publication Title

Journal of Autonomic Pharmacology

Abstract

1. Pretreatment with 6-OHDA or bilateral sectioning of the hypogastric nerves decreased the noradrenaline content of lower urinary tract tissue. 2. Pelvic nerve stimulation-induced contractions were not significantly changed by either 6-OHDA pretreatment or bilateral sectioning of the hypogastric nerves. 3. Hypogastric nerve stimulation-induced contractions were significantly attenuated by the pretreatments. 4. Neither ATP- nor acetylcholine-induced contractions were significantly altered by either 6-OHDA or bilateral sectioning of the hypogastric nerves. 5. The data indicate that ATP, released by pelvic nerve stimulation, which induces a bladder contraction, is released from parasympathetic, cholinergic nerve fibres in the pelvic nerve trunks and not sympathetic, nor adrenergic nerve fibres also present in the pelvic nerve trunks.

First Page

111

Last Page

115

DOI

10.1111/j.1474-8673.1996.tb00419.x

Publication Date

1-1-1996

This document is currently not available here.

Share

COinS