1,2,3,4-Tetrahydroisoquinoline and related analogs of the phenylalkylamine designer drug MDMA
Document Type
Article
Publication Title
Medicinal Chemistry Research
Abstract
1,2,3,4-Tetrahydroisoquinoline (TIQ) analogs of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) and its N-methyl derivative, MDMA, similar in structure to a TIQ metabolite of MDA, were prepared and examined (a) in tests of central stimulant activity in mice, (b) for their ability to bind at human 5-HT2A receptors, and (c) in tests of stimulus generalization in rats trained to discriminate MDMA from vehicle. In general, the TIQ analogs failed to display appreciable activity in any assay system. Conversely, certain 2-aminotetralin and 2-aminoindan analogs were active in the stimulus generalization studies. It is concluded that TIQ-like conformations do not account for the actions typically associated with MDA- and MDMA-related agents.
First Page
412
Last Page
426
Publication Date
12-1-1996
Recommended Citation
Malmusi, Luca; Dukat, Małgorzata; Young, Richard; Teitler, Milt; Darmani, Nissar A.; Ahmad, Bashir; Smith, Carol; and Glennon, Richard A., "1,2,3,4-Tetrahydroisoquinoline and related analogs of the phenylalkylamine designer drug MDMA" (1996). All KCOM Faculty Publications. 343.
https://scholarworks.atsu.edu/kcom-faculty/343