1,2,3,4-Tetrahydroisoquinoline analogs of phenylalkylamine stimulants and hallucinogens
Document Type
Article
Publication Title
Medicinal Chemistry Research
Abstract
Conformationally constrained, 1,2,3,4-tetrahydroisoquinoline (TIQ) analogs of central stimulant (e.g. amphetamine) and hallucinogenic (e.g. DOM) phenylalkylamines were prepared and evaluated to determine the contribution to activity of this conformational restriction. The amphetamine-related TIQs failed to produce locomotor stimulation in mice and did not produce amphetamine-appropriate responding in tests of stimulus generalization in (+)amphetamine-trained rats. Hallucinogen-related TIQs lacked appreciable affinity for 5-HT2A serotonin receptors and did not produce DOM-like effects in tests of stimulus generalization in DOM-trained rats. It is concluded that the phenylalkylamine conformation represented by the TIQs is not a major contributor to these actions.
First Page
400
Last Page
411
Publication Date
12-1-1996
Recommended Citation
Malmusi, Luca; Dukat, Małgorzata; Young, Richard; Teitler, Milt; Darmani, Nissar A.; Ahmad, Bashir; Smith, Carol; and Glennon, Richard A., "1,2,3,4-Tetrahydroisoquinoline analogs of phenylalkylamine stimulants and hallucinogens" (1996). All KCOM Faculty Publications. 342.
https://scholarworks.atsu.edu/kcom-faculty/342