Inhibition of motility and invasion of B16 melanoma by the overexpression of cystatin C

Document Type

Article

Publication Title

Melanoma Research

Abstract

Although increased expression of cysteine proteinases has been shown to be correlated with increased metastasis for a wide variety of tumours, the contribution of cysteine proteinases to the metastatic spread of tumour cella is not well understood. In order to examine this question we have overexpressed a specific cysteine proteinase inhibitor, cystatin C, by stable transfection of B16F10 melanoma. Increased expression of cystatin C inhibited motility and in vitro invasiveness of B16 melanoma by 50% in both stimulated (autocrine motility factor, laminin) and unstimulated cells. These results suggest that cysteine proteinases are involved in B16 melanoma motility and invasion.

First Page

97

Last Page

101

DOI

10.1097/00008390-199704000-00002

Publication Date

1-1-1997

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