ARYLAZIDO AMINOPROPIONYL ATP (ANAPP3) ANTAGONISM OF CAT URINARY BLADDER CONTRACTIONS

Document Type

Article

Publication Title

Journal of Autonomic Pharmacology

Abstract

1 ANAPP3 produces a transient contraction of the urinary bladder of the cat similar to that produced by ATP and hypogastric nerve stimulation. 2 ANAPP3 partially antagonizes the inhibition of pelvic nerve‐evoked bladder contractions induced by adenosine, possibly by blocking P1 receptors. 3 ANAPP3 antagonizes contractions of the cat urinary bladder induced by ATP, β, γ‐methylene ATP, pelvic nerve stimulation and hypogastric nerve stimulation. 4 ANAPP3 produces no antagonism of either noradrenaline‐induced inhibition of pelvic nerve‐evoked bladder contractions or acetylcholine‐induced bladder contractions, thereby substantiating the specificity of the effect of ANAPP3 against purines. Copyright © 1982, Wiley Blackwell. All rights reserved

First Page

175

Last Page

179

DOI

10.1111/j.1474-8673.1982.tb00487.x

Publication Date

1-1-1982

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