Lack of a functional methionine sulfoxide reductase (MsrB) increases oxacillin and H2O2 stress resistance and enhances pigmentation in Staphylococcus aureus

Document Type

Article

Publication Title

Canadian Journal of Microbiology

Abstract

Staphylococcus aureus produces 3 MsrA enzymes (MsrA1, MsrA2, and MsrA3) and 1 MsrB enzyme. The genes encoding MsrA1 and MsrB are the first and second genes of a 4-gene operon in S. aureus. In a previous study, MsrA1-deficient S. aureus cells showed increased sensitivity to oxidative stress conditions in spite of a higher production of MsrB. In this study, an msrB mutant of S. aureus was created by site-directed mutagenesis that left the first gene of this locus, msrA1, intact. Studies with this mutant suggest that a deletion of MsrB increases resistance of S. aureus to H2O2 and oxacillin and that the mutant cells produce a higher level of carotenoids relative to wild-type S. aureus cells.

First Page

625

Last Page

628

DOI

10.1139/cjm-2014-0360

Publication Date

7-1-2014

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