Mirna-146a and mirna-126 as potential biomarkers in patients with coronary artery disease and generalized periodontitis
Document Type
Article
Publication Title
Materials
Abstract
The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. A total of 75 participants were selected and grouped into three categories of 25 patients each: GP+CAD, GP, and HP groups. GP+CAD consisted of patients diagnosed with generalized periodontitis (GP) and coronary artery disease (CAD). The GP+CAD group was further divided into two groups—GP+CADa: where subgingival plaque samples were collected; GP+CADb group: where coronary plaque samples were collected while the patient underwent a coronary artery bypass grafting surgery. The GP group consisted of 25 patients diagnosed with only generalized periodontitis. The HP group consisted of 25 systemically and periodontally healthy controls. miRNA-146a and miRNA126 levels were assessed in subgingival plaque (SP) samples from all groups. Results revealed that miRNA-146a was expressed at higher levels and miRNA-126 was downregulated in the GP+CAD group. microRNAs in subgingival plaque samples showed a significant correlation with the coronary plaque samples in the GP+CAD group. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodonti-tis. These micro-RNAs may serve as risk biomarkers for coronary artery disease and generalized periodontitis.
DOI
10.3390/ma14164692
Publication Date
8-2-2021
Recommended Citation
Mahendra, Jaideep; Mahendra, Little; Fageeh, Hytham N.; Fageeh, Hammam Ibrahim; Ibraheem, Wael; Abdulkarim, Hesham H.; Kanakamedala, Anilkumar; Prakash, Prashanthi; Srinivasan, Sruthi; Balaji, Thodur Madapusi; Varadarajan, Saranya; Jagannathan, Raghunathan; and Patil, Shankargouda, "Mirna-146a and mirna-126 as potential biomarkers in patients with coronary artery disease and generalized periodontitis" (2021). MOSDOH Faculty Publications. 87.
https://scholarworks.atsu.edu/mosdoh-faculty/87