Management of Medication-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients With Pentoxifylline and Tocopherol: Case Reports
Document Type
Article
Publication Title
Case Reports in Dentistry
Abstract
Medication-related osteonecrosis of the jaw (MRONJ) is a well-known side effect of bone-modifying agents such as antiresorptive medications including pamidronic and zoledronic acids (intravenous bisphosphonates) and denosumab (anti-RANK ligand humanized monoclonal antibody). The major risk factor for the precipitation of MRONJ in a patient taking antiresorptive medication is dentoalveolar trauma such as dental extractions. Management of MRONJ in oncology patients is exceptionally challenging. In this report, two multiple myeloma patients with longstanding advanced-stage MRONJ were successfully managed with combined pentoxifylline–tocopherol treatment pre- and postextraction/sequestrectomy. In conclusion, based on this report and other published reports, it appears that the use of combined pentoxifylline–tocopherol protocol in the management of MRONJ is effective.
DOI
10.1155/crid/2765925
Publication Date
1-1-2025
Recommended Citation
Owosho, Adepitan A.; DeColibus, Katherine A.; Levy, Layne C.; and Okhuaihesuyi, Osariemen, "Management of Medication-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients With Pentoxifylline and Tocopherol: Case Reports" (2025). MOSDOH Faculty Publications. 170.
https://scholarworks.atsu.edu/mosdoh-faculty/170