Gut inflammation in response to injury: Potential target for therapeutic intervention
Document Type
Article
Publication Title
Recent Patents on Anti-Infective Drug Discovery
Abstract
Traumatic injuries present a major public health concern worldwide. A role of gut and/or its derived factors has been suggested in the pathogenesis associated with injury. Injury causes the activation of various signaling pathways along with the release and activation of pro-inflammatory cytokines, chemokines and adhesion molecules in the intestine. This mediates infiltration of neutrophils into the intestine. Primed and subsequently activated neutrophils release various proteolytic enzymes and superoxide anion which ultimately result in intestinal inflammation and/or injury. This review will discuss the various factors contributing to intestinal inflammation following injury. Some of the patents relevant to intestinal inflammation have also been discussed in the present manuscript. © 2011 Bentham Science Publishers.
First Page
206
Last Page
215
DOI
10.2174/157489111796887837
Publication Date
9-1-2011
Recommended Citation
Akhtar, Suhail and Choudhry, Mashkoor A., "Gut inflammation in response to injury: Potential target for therapeutic intervention" (2011). Biomedical Sciences Faculty Publications. 24.
https://scholarworks.atsu.edu/biomed-faculty/24